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Trials
A Study of Emavusertib + An Approved Bruton Tyrosine Kinase Inhibitor (BTKi) in Participants With Chronic Lymphocytic Leukemia (CLL) and Other B-cell Malignancies

trialsTrialRecruiting

A Study of Emavusertib + An Approved Bruton Tyrosine Kinase Inhibitor (BTKi) in Participants With Chronic Lymphocytic Leukemia (CLL) and Other B-cell Malignancies

A phase 2 trial of Zanubrutinib in chronic lymphocytic leukaemia, run by Curis, Inc., now recruiting.

Overview Connected4

Overview

A Study of Emavusertib + An Approved Bruton Tyrosine Kinase Inhibitor (BTKi) in Participants With Chronic Lymphocytic Leukemia (CLL) and Other B-cell Malignancies is a phase 2 interventional study registered as NCT07271667 by Curis, Inc., with 108 participants planned, started 2026-04-23 and due to reach its primary completion in 2027-11. Interventions recorded: Emavusertib and Zanubrutinib.

Setting

A Phase 2 Study of Emavusertib in Combination With an Approved Bruton Tyrosine Kinase Inhibitor in Patients With Chronic Lymphocytic Leukemia and Other B-cell Malignancies

Phase

Phase 2

Sponsor

Curis, Inc.

Registry

Started

2026-04-23

Enrolled

108 enrolled

Connected

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cancers

Chronic lymphocytic leukaemia

drugs

Phase 2Oral serine/threonine kinase inhibitor

ApprovedSmall-molecule covalent BTK inhibitor (second generation)

Zanubrutinib · Brukinsa

companies

Evidence strength30/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
108 enrolled+10
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-17 · Jude Gomila · Reverse links for orphaned drugs and companies · diff · file

Sources & links

ClinicalTrials.gov NCT07271667

Data

JSON ·

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Cancers

Chronic lymphocytic leukaemia

Products

Zanubrutinib
Emavusertib

Companies

Curis

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