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Trials
Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With

trialsTrialRecruiting

Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With

A phase 1/2 trial of PF-08634404, Ipilimumab, Axitinib in renal cell carcinoma, run by Pfizer, now recruiting.

Also called: Symbiotic-GU-08

Overview Connected5

Overview

Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer is a phase 1/2 interventional study registered as NCT07227415 by Pfizer, with 224 participants planned, started 2026-02-10 and due to reach its primary completion in 2027-11-02. Interventions recorded: PF-08634404, Ipilimumab, Axitinib. Conditions listed: Carcinoma, Renal Cell, Advanced Renal Cell Carcinoma, Renal Cancer, Renal Neoplasm. No results are recorded here; the registry entry is the source.

Setting

AN INTERVENTIONAL PHASE 1B/2 STUDY TO EVALUATE THE SAFETY AND EFFICACY OF PF-08634404 MONOTHERAPY AND IN COMBINATION WITH OTHER ANTICANCER AGENTS IN ADULT PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC RENAL CELL CARCINOMA

Phase

Phase 1/2

Sponsor

Pfizer

Registry

Started

2026-02-10

Enrolled

224 enrolled

Connected

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cancers

Renal cell carcinoma

drugs

ApprovedSmall-molecule kinase inhibitor (VEGFR)

Axitinib · Inlyta

ApprovedMonoclonal antibody (anti-CTLA-4)

Ipilimumab · Yervoy

Phase 3bispecific antibody (PD-1 x VEGF, per the sponsor's pipeline page; form not stated in the registry record)

companies

Pfizer (incl. Seagen)

Evidence strength25/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
224 enrolled+12
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Trial acronyms for registry records · diff · file

Sources & links

ClinicalTrials.gov NCT07227415

Data

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Cancers

Renal cell carcinoma

Products

PF-08634404
Ipilimumab
Axitinib

Companies

Pfizer (incl. Seagen)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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