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Trials
Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

trialsTrialRecruiting

Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

A phase 1/2 trial of PF-08634404, PF-08046054 in non-small-cell lung cancer and small-cell lung cancer, run by Pfizer, now recruiting.

Also called: Symbiotic-Lung-20

Overview Connected5

Overview

Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers is a phase 1/2 interventional study registered as NCT07227298 by Pfizer, with 162 participants planned, started 2026-01-30 and due to reach its primary completion in 2029-03-08. Interventions recorded: PF-08634404, Sigvotatug Vedotin, PF-08046054/SGN-PDL1V. Conditions listed: Advanced/Metastatic Non-Small Cell Lung Cancer, Carcinoma, Non-Small Cell Lung, Non-Small Cell Lung Cancer. No results are recorded here; the registry entry is the source.

Setting

AN INTERVENTIONAL OPEN-LABEL PHASE 1B/2 STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS, AND PRELIMINARY EFFICACY OF PF-08634404 IN COMBINATION WITH DIFFERENT ANTICANCER AGENTS IN PARTICIPANTS WITH ADVANCED SOLID TUMORS

Phase

Phase 1/2

Sponsor

Pfizer

Registry

Started

2026-01-30

Enrolled

162 enrolled

Connected

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cancers

Non-small-cell lung cancer Small-cell lung cancer

drugs

Phase 3ADC

Phase 3bispecific antibody (PD-1 x VEGF, per the sponsor's pipeline page; form not stated in the registry record)

companies

Pfizer (incl. Seagen)

Evidence strength19/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
162 enrolled+11
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Trial acronyms for registry records · diff · file

Sources & links

ClinicalTrials.gov NCT07227298

Data

JSON ·

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Cancers

Non-small-cell lung cancer
Small-cell lung cancer

Products

PF-08634404
PF-08046054

Companies

Pfizer (incl. Seagen)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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