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Trials
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)

trialsTrialRecruiting

A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)

A phase 1/2 trial of Risvutatug Rezetecan in advanced solid tumours, run by GlaxoSmithKline, now recruiting.

Also called: EMBOLD PanGI-201

Overview Connected2

Overview

A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201) is a phase 1/2 interventional study registered as NCT06885034 by GlaxoSmithKline, with 451 participants planned, started 2025-06-11 and due to reach its primary completion in 2028-01-10. Interventions recorded: Risvutatug Rezetecan, Drug 1, Drug 2, Drug 3 and Drug 4.

Setting

A Phase1 b/2, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of GSK5764227 Alone and in Combination in Participants With Previously Treated Advanced Unresectable or Metastatic Gastrointestinal Solid Tumors

Phase

Phase 1/2

Sponsor

GlaxoSmithKline

Registry

Started

2025-06-11

Enrolled

451 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

companies

Evidence strength21/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
451 enrolled+13
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Trial acronyms for registry records · diff · file

Sources & links

ClinicalTrials.gov NCT06885034

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