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Trials
A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2)

trialsTrialRecruiting

A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2)

A phase 1/2 trial of Dostarlimab and Bevacizumab in advanced solid tumours, run by GlaxoSmithKline, now recruiting.

Also called: BEHOLD-2

Overview Connected4

Overview

A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2) is a phase 1/2 interventional study registered as NCT06796907 by GlaxoSmithKline, with 305 participants planned, started 2025-03-04 and due to reach its primary completion in 2027-06-21. Interventions recorded: Mo-Rez, Dostarlimab and Bevacizumab.

Setting

A Phase 1/2 Randomized Multi-Cohort Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of Mocertatug Rezetecan in Combination With Anti-Cancer Agents in Participants With Advanced Solid Tumors

Phase

Phase 1/2

Sponsor

GlaxoSmithKline

Registry

Started

2025-03-04

Enrolled

305 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

ApprovedMonoclonal antibody (anti-VEGF)

Bevacizumab · Avastin (and biosimilars)

ApprovedMonoclonal antibody (anti-PD-1)

Dostarlimab · Jemperli

companies

Evidence strength25/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
305 enrolled+12
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Trial acronyms for registry records · diff · file

Sources & links

ClinicalTrials.gov NCT06796907

Data

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Bevacizumab

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