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Trials
Lead-212 PSV359 Therapy for Patients With Solid Tumors

trialsTrialRecruiting

Lead-212 PSV359 Therapy for Patients With Solid Tumors

A phase 1/2 trial of [203Pb]Pb-PSV359 in pancreatic ductal adenocarcinoma, gastric & gastro-oesophageal junction cancer, oesophageal cancer, colorectal cancer, ovarian cancer and head and neck squamous cell carcinoma, run by Perspective Therapeutics, now recruiting.

Overview Connected7

Overview

Lead-212 PSV359 Therapy for Patients With Solid Tumors is a phase 1/2 interventional study registered as NCT06710756 by Perspective Therapeutics, with 112 participants planned, started 2025-04-28 and due to reach its primary completion in 2028-01-31. Interventions recorded: [203Pb]Pb-PSV359 and [212Pb]Pb-PSV359.

Setting

A Phase I/IIa Image-Guided, Alpha-Particle Therapy Study of [203Pb]Pb-PSV359 and [212Pb]Pb-PSV359 in Patients With Solid Tumors That Are Known to be Fibroblast Activation Protein (FAP)-Positive

Phase

Phase 1/2

Sponsor

Perspective Therapeutics

Registry

Started

2025-04-28

Enrolled

112 enrolled

Connected

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cancers

Colorectal cancer Gastric & gastro-oesophageal junction cancer Head and neck squamous cell carcinoma Oesophageal cancer Ovarian cancer Pancreatic ductal adenocarcinoma

companies

Perspective Therapeutics

Evidence strength18/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
112 enrolled+10
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-16 · Jude Gomila · Registry trials wave 6 and products wave 7 · diff · file

Sources & links

ClinicalTrials.gov NCT06710756

Data

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Cancers

Pancreatic ductal adenocarcinoma
Gastric & gastro-oesophageal junction cancer
Oesophageal cancer
Colorectal cancer
Ovarian cancer
Head and neck squamous cell carcinoma

Companies

Perspective Therapeutics

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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