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Trials
Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors

trialsTrialRecruiting

Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors

A phase 1/2 trial of TH9619 in colorectal cancer, head and neck squamous cell carcinoma, non-small-cell lung cancer and gastric & gastro-oesophageal junction cancer, run by One-carbon Therapeutics AB, now recruiting.

Also called: ODIN

Overview Connected4

Overview

Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT07151040 by One-carbon Therapeutics AB, with 43 participants planned, started 2025-08-22 and due to reach its primary completion in 2026-12. Interventions recorded: TH9619.

Setting

A First-in-human, Phase 1/2, Multicenter, Open-label, Dose Escalation, Confirmation and Expansion Study to Evaluate the Safety, Pharmacokinetics and Antitumor Activity of TH9619 in Subjects With Advanced Solid Tumors

Phase

Phase 1/2

Sponsor

One-carbon Therapeutics AB

Registry

Started

2025-08-22

Enrolled

43 enrolled

Connected

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cancers

Colorectal cancer Gastric & gastro-oesophageal junction cancer Head and neck squamous cell carcinoma Non-small-cell lung cancer

Evidence strength16/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
43 enrolled+8
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Add 115 registry trial acronyms from the CT.gov acronym f… · diff · file

Sources & links

ClinicalTrials.gov NCT07151040

Data

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Cancers

Colorectal cancer
Head and neck squamous cell carcinoma
Non-small-cell lung cancer
Gastric & gastro-oesophageal junction cancer

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