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Trials
A Study of Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Renal Cell Carcinoma (V940-004).

trialsTrialActive

A Study of Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Renal Cell Carcinoma (V940-004).

A phase 2 trial of Intismeran autogene, Pembrolizumab in renal cell carcinoma, run by Merck Sharp & Dohme LLC, active and no longer recruiting.

Also called: INTerpath-004

Overview Connected6

Overview

A Study of Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Renal Cell Carcinoma (V940-004). is a phase 2 interventional study registered as NCT06307431 by Merck Sharp & Dohme LLC, with 272 participants planned, started 2024-04-10 and due to reach its primary completion in 2028-01-08. Interventions recorded: Intismeran autogene, Pembrolizumab, Placebo. Conditions listed: Renal Cell Carcinoma. No results are recorded here; the registry entry is the source.

Setting

A Phase 2, Randomized, Double-blind, Clinical Study of V940 (mRNA-4157) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in the Adjuvant Treatment of Participants With Renal Cell Carcinoma (INTerpath-004).

Phase

Phase 2

Sponsor

Merck Sharp & Dohme LLC

Registry

Started

2024-04-10

Enrolled

272 enrolled

Connected

Similar pages

Trial
A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)
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A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (
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A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)
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A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005)
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A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
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A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)
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Trial
A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I
Shares Intismeran autogene, Personalised neoantigen (mRNA) vaccines, Merck & Co. (MSD).
Pairing
Personalised neoantigen vaccine + PD-1 blockade
Shares Intismeran autogene, Personalised neoantigen (mRNA) vaccines, Pembrolizumab, Immune checkpoint inhibitors.

cancers

Renal cell carcinoma

technologies

Immune checkpoint inhibitors Personalised neoantigen (mRNA) vaccines

drugs

Phase 3Personalised mRNA neoantigen vaccine

Intismeran autogene

ApprovedMonoclonal antibody (anti-PD-1)

Pembrolizumab · Keytruda / Keytruda Qlex (SC)

companies

Merck & Co. (MSD)

Evidence strength32/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
272 enrolled+12
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT06307431

Data

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Cancers

Renal cell carcinoma

Technologies

Immune checkpoint inhibitors
Personalised neoantigen (mRNA) vaccines

Products

Intismeran autogene
Pembrolizumab

Companies

Merck & Co. (MSD)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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