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Trials
A Study of PLB1001 Enteric Capsules in the Treatment of sGBM/IDH Mutant Glioblastoma Patients With the ZM Fusion Gene (FUGEN).

trialsTrialActive

A Study of PLB1001 Enteric Capsules in the Treatment of sGBM/IDH Mutant Glioblastoma Patients With the ZM Fusion Gene (FUGEN).

A phase 2/3 trial of Vebreltinib run by Beijing Pearl Biotechnology Limited Liability Company, active.

Overview Connected5

Overview

A Study of PLB1001 Enteric Capsules in the Treatment of sGBM/IDH Mutant Glioblastoma Patients With the ZM Fusion Gene (FUGEN). is a phase 2/3 interventional study registered as NCT06105619 by Beijing Pearl Biotechnology Limited Liability Company, with 84 participants enrolled, started 2018-10-08. Conditions listed: Glioblastoma. No results are recorded here; the registry entry is the source.

Setting

A Randomized, Controlled, Open, Multicenter, Phase II/III Clinical Study to Evaluate the Safety and Efficacy of Vebreltinib Enteric Capsules in the Treatment of sGBM/IDH Mutant Glioblastoma Patients With the ZM Fusion Gene (FUGEN).

Phase

Phase 2/3

Sponsor

Beijing Pearl Biotechnology Limited Liability Company

Registry

Started

2018-10-08

Enrolled

84 enrolled

Connected

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cancers

Astrocytoma, IDH-mutant (grades 2 to 4)Glioma & glioblastoma

technologies

Small-molecule kinase inhibitors

drugs

ApprovedOral selective MET tyrosine kinase inhibitor

companies

Beijing Pearl Biotechnology Limited Liability Company

Evidence strength37/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2/3+22
84 enrolled+10
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT06105619

Data

JSON ·

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Cancers

Glioma & glioblastoma
Astrocytoma, IDH-mutant (grades 2 to 4)

Technologies

Small-molecule kinase inhibitors

Products

Vebreltinib

Companies

Beijing Pearl Biotechnology Limited Liability Company

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

Machine-readable versions of A Study of PLB1001 Enteric Capsules in the Treatment of sGBM/IDH Mutant Glioblastoma Patients With the ZM Fusion Gene (FUGEN).

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MCP server: npx -y onco-mcp, tools search, get_entity, list_kind, ask, context, compare. This record is get_entity or context with id nct06105619.

WebMCP tools registered on this page: onco_search, onco_get_entity.