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Trials
A Study of RC118 Plus Toripalimab / RC148 in Patients with Locally Advanced Unresectable or Metastatic Solid Tumors

trialsTrialRecruiting

A Study of RC118 Plus Toripalimab / RC148 in Patients with Locally Advanced Unresectable or Metastatic Solid Tumors

A phase 1/2 trial of RC118-ADC, Toripalimab and RC148 in advanced solid tumours, run by RemeGen Co., Ltd., now recruiting.

Overview Connected6

Overview

A Study of RC118 Plus Toripalimab / RC148 in Patients with Locally Advanced Unresectable or Metastatic Solid Tumors is a phase 1/2 interventional study registered as NCT06038396 by RemeGen Co., Ltd., with 48 participants planned, started 2023-08-03 and due to reach its primary completion in 2026-02-28. Interventions recorded: RC118, Toripalimab and RC148.

Setting

A Phase I/II Clinical Study to Evaluate the Safety and Efficacy of RC118 in Combination with Toripalimab / RC148 for Patients with Claudin 18.2-Positive, Locally Advanced Unresectable or Metastatic Malignant Solid Tumors

Phase

Phase 1/2

Sponsor

RemeGen Co., Ltd.

Registry

Started

2023-08-03

Enrolled

48 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

Immune checkpoint inhibitors

drugs

Phase 2ADC

Phase 3bispecific antibody (PD-1 x VEGF, per the sponsor's pipeline page; form not stated in the registry record)

ApprovedMonoclonal antibody (anti-PD-1)

Toripalimab · Loqtorzi

companies

Evidence strength21/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
48 enrolled+8
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT06038396

Data

JSON ·

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How review works

Cancers

Metastatic cancer (cancer that has spread)

Technologies

Immune checkpoint inhibitors

Products

RC118-ADC
Toripalimab
RC148

Companies

RemeGen

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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