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Trials
A LM-302 Combination With Other Anti-Tumor Therapies Phase ll Study

trialsTrialRecruiting

A LM-302 Combination With Other Anti-Tumor Therapies Phase ll Study

A phase 2 trial of LM-302, Toripalimab, Capecitabine, Nivolumab, Rivoceranib (apatinib) and Gemcitabine in advanced solid tumours, run by LaNova Medicines Zhejiang Co., Ltd., now recruiting.

Overview Connected8

Overview

A LM-302 Combination With Other Anti-Tumor Therapies Phase ll Study is a phase 2 interventional study registered as NCT05934331 by LaNova Medicines Zhejiang Co., Ltd., with 276 participants planned, started 2023-07-27 and due to reach its primary completion in 2026-07-01. Interventions recorded: LM-302, Toripalimab, Capecitabine, Tegafur, Gimeracil and Oteracil Potassium Capsules, Nivolumab and Apatinib.

Setting

An Open-label, Multicenter Phase II Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of the LM-302 Combination With Other Anti-tumor Treatment in Subjects With CLDN18.2-positive Advanced Gastro-Intestinal Cancer.

Phase

Phase 2

Sponsor

LaNova Medicines Zhejiang Co., Ltd.

Registry

Started

2023-07-27

Enrolled

276 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

ApprovedOral fluoropyrimidine prodrug (antimetabolite)

Capecitabine · Xeloda

ApprovedNucleoside analogue (deoxycytidine)

Gemcitabine · Gemzar / Infugem

Phase 3ADC

ApprovedMonoclonal antibody (anti-PD-1)

Nivolumab · Opdivo / Opdivo Qvantig (SC)

ApprovedSmall-molecule VEGFR2 TKI

Rivoceranib (apatinib) · Aitan

ApprovedMonoclonal antibody (anti-PD-1)

Toripalimab · Loqtorzi

companies

LaNova Medicines

Evidence strength32/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
276 enrolled+12
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Orphan trials · diff · file

Sources & links

ClinicalTrials.gov NCT05934331

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Products

LM-302
Toripalimab
Capecitabine
Nivolumab
Rivoceranib (apatinib)
Gemcitabine

Companies

LaNova Medicines

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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