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Trials
A Study of LM-108 as Monotherapy or in Combination With Antitumor Therapies in Subjects With Advanced Solid Tumors

trialsTrialActive

A Study of LM-108 as Monotherapy or in Combination With Antitumor Therapies in Subjects With Advanced Solid Tumors

A phase 1/2 trial of LM-108 and Toripalimab in advanced solid tumours, run by LaNova Medicines Limited, active and no longer recruiting.

Overview Connected4

Overview

A Study of LM-108 as Monotherapy or in Combination With Antitumor Therapies in Subjects With Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT05518045 by LaNova Medicines Limited, with 392 participants enrolled, started 2022-08-26 and due to reach its primary completion in 2026-10-31. Interventions recorded: LM-108 and Toripalimab.

Setting

An Open-Label, Dose-Escalation and Dose-Expansion Phase I/II Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Profile and Preliminary Efficacy of LM-108 for Injection as Monotherapy or in Combination With Antitumor Therapies in Patients With Advanced Solid Tumors

Phase

Phase 1/2

Sponsor

LaNova Medicines Limited

Registry

Started

2022-08-26

Enrolled

392 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

Phase 3monoclonal antibody

ApprovedMonoclonal antibody (anti-PD-1)

Toripalimab · Loqtorzi

companies

LaNova Medicines

Evidence strength26/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
392 enrolled+13
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-16 · Jude Gomila · Registry trials wave 6 and products wave 7 · diff · file

Sources & links

ClinicalTrials.gov NCT05518045

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Products

LM-108
Toripalimab

Companies

LaNova Medicines

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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