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Trials
A Study of DB-1310 in Advanced/Metastatic Solid Tumors

trialsTrialRecruiting

A Study of DB-1310 in Advanced/Metastatic Solid Tumors

A phase 1/2 trial of Trastuzumab, Osimertinib and Capecitabine in advanced solid tumours, run by DualityBio Inc., now recruiting.

Overview Connected5

Overview

A Study of DB-1310 in Advanced/Metastatic Solid Tumors is a phase 1/2 interventional study registered as NCT05785741 by DualityBio Inc., with 1000 participants planned, started 2023-08-17 and due to reach its primary completion in 2027-12-30. Interventions recorded: DB-1310, Trastuzumab, Osimertinib and capecitabine.

Setting

A Phase 1/2a, Multicenter, Open-Label, First in Human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of DB-1310 in Subjects With Advanced/Metastatic Solid Tumors

Phase

Phase 1/2

Sponsor

DualityBio Inc.

Registry

Started

2023-08-17

Enrolled

1,000 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

ApprovedOral fluoropyrimidine prodrug (antimetabolite)

Capecitabine · Xeloda

ApprovedSmall-molecule kinase inhibitor (EGFR)

Osimertinib · Tagrisso

ApprovedMonoclonal antibody (anti-HER2)

Trastuzumab · Herceptin (and biosimilars, Phesgo with pertuzumab)

companies

Duality Biotherapeutics

Evidence strength28/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
1,000 enrolled+15
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-16 · Jude Gomila · Registry trials wave 6 and products wave 7 · diff · file

Sources & links

ClinicalTrials.gov NCT05785741

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Products

Trastuzumab
Osimertinib
Capecitabine

Companies

Duality Biotherapeutics

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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