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Trials
A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

trialsTrialRecruiting

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

A phase 1/2 trial of BNT324 and PM8002 in advanced solid tumours, run by BioNTech SE, now recruiting.

Overview Connected5

Overview

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer is a phase 1/2 interventional study registered as NCT06892548 by BioNTech SE, with 594 participants planned, started 2025-05-02 and due to reach its primary completion in 2028-09. Interventions recorded: BNT324 and BNT327.

Setting

A Phase Ib/II, Multi-site, Open-label, Two-part Trial to Evaluate the Efficacy, Safety, Pharmacokinetics, and Recommended Combination Dose of BNT324 With BNT327 in Participants With Advanced Lung Cancer

Phase

Phase 1/2

Sponsor

BioNTech SE

Registry

Started

2025-05-02

Enrolled

594 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

Phase 3ADC

Phase 3bispecific antibody

companies

BioNTech Duality Biotherapeutics

Evidence strength22/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
594 enrolled+14
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-16 · Jude Gomila · Registry trials wave 6 and products wave 7 · diff · file

Sources & links

ClinicalTrials.gov NCT06892548

Data

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Cancers

Metastatic cancer (cancer that has spread)

Products

BNT324
PM8002

Companies

BioNTech
Duality Biotherapeutics

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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