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Trials
S-531011 as Monotherapy and in Combination With an Immune Checkpoint Inhibitor in Advanced or Metastatic Solid Tumors

trialsTrialRecruiting

S-531011 as Monotherapy and in Combination With an Immune Checkpoint Inhibitor in Advanced or Metastatic Solid Tumors

A phase 1/2 trial of Pembrolizumab and Bevacizumab in advanced solid tumours, run by Shionogi, now recruiting.

Also called: aCCeleR8-001

Overview Connected4

Overview

S-531011 as Monotherapy and in Combination With an Immune Checkpoint Inhibitor in Advanced or Metastatic Solid Tumors is a phase 1/2 interventional study registered as NCT05101070 by Shionogi, with 282 participants planned, started 2022-05-30 and due to reach its primary completion in 2028-05-31. Interventions recorded: S-531011, Pembrolizumab and Bevacizumab.

Setting

A Phase 1b/2, Multicenter, Open-label Study of S-531011 as Monotherapy and in Combination With an Immune Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

Phase

Phase 1/2

Sponsor

Shionogi

Registry

Started

2022-05-30

Enrolled

282 enrolled

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cancers

Metastatic cancer (cancer that has spread)

drugs

ApprovedMonoclonal antibody (anti-VEGF)

Bevacizumab · Avastin (and biosimilars)

ApprovedMonoclonal antibody (anti-PD-1)

Pembrolizumab · Keytruda / Keytruda Qlex (SC)

companies

Merck & Co. (MSD)

Evidence strength25/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
282 enrolled+12
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · A further 160 trial acronyms added as aliases to registry… · diff · file

Sources & links

ClinicalTrials.gov NCT05101070

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Products

Pembrolizumab
Bevacizumab

Companies

Merck & Co. (MSD)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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