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Trials
Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors

trialsTrialActive

Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors

A phase 1/2 trial of Pembrolizumab in advanced solid tumours, run by Nouscom SRL, active and no longer recruiting.

Overview Connected5

Overview

Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors is a phase 1/2 interventional study registered as NCT04041310 by Nouscom SRL, with 115 participants enrolled, started 2019-10-21 and due to reach its primary completion in 2026-10-30. Interventions recorded: GAd-209-FSP low dose, MVA-209-FSP low dose, GAd-209-FSP high dose, MVA-209-FSP high dose, GAd20-209-FSP, RP2D and MVA-209-FSP, RP2D.

Setting

A Phase I/II, Multicenter, Open-Label Study of Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors

Phase

Phase 1/2

Sponsor

Nouscom SRL

Registry

Started

2019-10-21

Enrolled

115 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

Immune checkpoint inhibitors

drugs

ApprovedMonoclonal antibody (anti-PD-1)

Pembrolizumab · Keytruda / Keytruda Qlex (SC)

companies

Merck & Co. (MSD)Nouscom

Evidence strength23/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
115 enrolled+10
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT04041310

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

Immune checkpoint inhibitors

Products

Pembrolizumab

Companies

Nouscom
Merck & Co. (MSD)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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