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Trials
A Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TST001 in Advanced or Metastatic Solid Tumors

trialsTrialRecruiting

A Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TST001 in Advanced or Metastatic Solid Tumors

A phase 1/2 trial of CAPOX, Capecitabine, Paclitaxel / nab-paclitaxel in metastatic cancer, run by Transcenta Therapeutics (Hangzhou) Co., Ltd., now recruiting.

Overview Connected9

Overview

A Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TST001 in Advanced or Metastatic Solid Tumors is a phase 1/2 interventional study registered as NCT04495296 by Transcenta Therapeutics (Hangzhou) Co., Ltd., with 320 participants planned, started 2020-08-13 and due to reach its primary completion in 2026-06-25. Interventions recorded: TST001, Oxaliplatin, Capecitabine, Paclitaxel, Gemcitabine. Conditions listed: Advanced Cancer. No results are recorded here; the registry entry is the source.

Setting

A Phase I/IIa Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TST001 - Claudin18.2 Monoclonal Antibody in the Treatment of Locally Advanced or Metastatic Solid Tumors

Phase

Phase 1/2

Sponsor

Transcenta Therapeutics (Hangzhou) Co., Ltd.

Registry

Started

2020-08-13

Enrolled

320 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

ApprovedOral fluoropyrimidine prodrug (antimetabolite)

Capecitabine · Xeloda

ApprovedCytotoxic regimen

CAPOX (capecitabine, oxaliplatin)

ApprovedCytotoxic chemotherapy (platinum)

Cisplatin · Platinol (generic)

ApprovedNucleoside analogue (deoxycytidine)

Gemcitabine · Gemzar / Infugem

ApprovedMonoclonal antibody (anti-PD-1)

Nivolumab · Opdivo / Opdivo Qvantig (SC)

ApprovedCytotoxic chemotherapy (taxane)

Paclitaxel / nab-paclitaxel · Taxol / Abraxane

Phase 2Monoclonal antibody

companies

Evidence strength26/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
320 enrolled+13
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-17 · Jude Gomila · Reverse links for orphaned drugs and companies · diff · file

Sources & links

ClinicalTrials.gov NCT04495296

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Products

CAPOX (capecitabine, oxaliplatin)
Capecitabine
Paclitaxel / nab-paclitaxel
Gemcitabine
Cisplatin
Nivolumab
TST001

Companies

Transcenta

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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