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How abnormal the cancer cells look under the microscope, from grade 1 (close to normal, slow) to grade 3 or 4 (wildly abnormal, fast). Grade is about behaviour; stage is about extent.
Pathologists assign grade from how well the cells resemble their parent tissue (differentiation), how variable their nuclei are, and how many are dividing; the schemes are tumour-specific, such as the Nottingham score in breast, Gleason in prostate, and WHO grades 1 to 4 in brain tumours. High grade predicts faster growth and earlier spread but also, often, better response to chemotherapy, and grade feeds into decisions about whether to add chemotherapy after surgery. Grade should not be confused with the 'grade' of a side effect, which is a separate severity scale.
Shares Solid pseudopapillary neoplasm of the pancreas, Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells, Classical versus basal-like (squamous) subtypes of pancreatic cancer, and GATA6, Adenosquamous carcinoma of the pancreas.
Shares Solid pseudopapillary neoplasm of the pancreas, Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells, Adenosquamous carcinoma of the pancreas, Colloid (mucinous non-cystic) carcinoma of the pancreas.
Shares AJCC 8th edition prognostic stage for breast cancer, Nottingham Prognostic Index (NPI), and PREDICT, Grade, stage and receptor status: three different things on one breast report, Stage.
Shares Pancreatic intraepithelial neoplasia (PanIN), the microscopic precursor of pancreatic cancer, Colloid (mucinous non-cystic) carcinoma of the pancreas, Mucinous cystic neoplasm of the pancreas with associated invasive carcinoma (MCN-associated carcinoma), Invasive carcinoma arising in an intraductal papillary mucinous neoplasm (IPMN-associated carcinoma).
Shares Solid pseudopapillary neoplasm of the pancreas, Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells, Adenosquamous carcinoma of the pancreas, Colloid (mucinous non-cystic) carcinoma of the pancreas.
Shares Nottingham Prognostic Index (NPI), and PREDICT, Nottingham grade (breast cancer grade 1, 2 and 3), Grade, stage and receptor status: three different things on one breast report, Stage.
Shares Nottingham Prognostic Index (NPI), and PREDICT, Nottingham grade (breast cancer grade 1, 2 and 3), Grade, stage and receptor status: three different things on one breast report, Breast cancer (all types).
Shares GIST risk stratification (mitotic count, size, site; Miettinen and modified NIH criteria), Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells, Adenosquamous carcinoma of the pancreas, Mucinous cystic neoplasm of the pancreas with associated invasive carcinoma (MCN-associated carcinoma).