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Cancer cells growing along the sheath of a nerve. Nerves act as tracks for spread, so this finding predicts recurrence, especially in pancreatic, prostate and head and neck cancers.
Nearly universal in pancreatic cancer (explaining its pain and local recurrence), common in prostate cancer biopsies and in cutaneous squamous and salivary cancers, PNI is an adverse pathological feature that can trigger adjuvant radiotherapy or wider margins. Biologically, nerves and tumours signal to each other (adrenergic and cholinergic signalling drive proliferation), which underpins the cancer neuroscience field and trials of beta-blockers and denervation. It is recorded in nearly every pathology report as present or absent.
Showing the technology this term belongs to: Cancer neuroscience: cutting the nerve supply.
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Shares The subtype and grade on a cutaneous squamous cell carcinoma report, How skin carcinoma is staged in Britain: UICC TNM, and why it is not the American system, Bowen's disease (squamous cell carcinoma in situ), Cutaneous squamous cell carcinoma.
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Shares What makes a skin cancer high risk: the UK feature lists, Bowen's disease (squamous cell carcinoma in situ), Resection margins (R0 / R1 / R2), Cutaneous squamous cell carcinoma.
Shares The subtype and grade on a cutaneous squamous cell carcinoma report, Bowen's disease (squamous cell carcinoma in situ), Cutaneous squamous cell carcinoma, Basal cell carcinoma.