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The chemotherapy (with or without whole-body radiation) given in the days before a stem cell transplant to destroy the diseased marrow and, for donor transplants, suppress the patient's immune system so the graft is not rejected.
Myeloablative conditioning (busulfan-cyclophosphamide, cyclophosphamide-TBI, high-dose melphalan for myeloma, BEAM for lymphoma) gives maximal anti-leukaemic effect but is tolerable only under about 60; reduced-intensity and non-myeloablative regimens (fludarabine-based, low-dose TBI, treosulfan) rely on the donor immune effect and have extended allogeneic transplant to older patients at the cost of higher relapse. Regimen choice is a trade-off between relapse and toxicity (mucositis, organ damage, infertility, veno-occlusive disease). Lymphodepletion before CAR-T is a milder cousin of the same idea.
Showing the molecule this term concerns: Melphalan (including hepatic delivery system).
Shares Bone, eyes, kidneys and lungs after transplant, Hormones, metabolism and the heart after transplant, Second cancers after allogeneic transplant, Fertility, growth and what total body irradiation costs.
Shares Preventing graft-versus-host disease, and what prevention costs, Bone, eyes, kidneys and lungs after transplant, Hormones, metabolism and the heart after transplant, Second cancers after allogeneic transplant.
Shares Bone, eyes, kidneys and lungs after transplant, Second cancers after allogeneic transplant, Chronic graft-versus-host disease, Graft-versus-host disease (GVHD) and graft-versus-leukaemia.
Shares Fertility, growth and what total body irradiation costs, Chronic graft-versus-host disease, Late effects after a stem cell transplant, Graft-versus-host disease (GVHD) and graft-versus-leukaemia.
Shares Second cancers after allogeneic transplant, Chronic graft-versus-host disease, Late effects after a stem cell transplant.
Shares Treosulfan, Preventing graft-versus-host disease, and what prevention costs, Bone, eyes, kidneys and lungs after transplant, Hormones, metabolism and the heart after transplant.
Shares Bone, eyes, kidneys and lungs after transplant, Chronic graft-versus-host disease, Graft-versus-host disease (GVHD) and graft-versus-leukaemia.
Shares Preventing graft-versus-host disease, and what prevention costs, Chronic graft-versus-host disease, Graft-versus-host disease (GVHD) and graft-versus-leukaemia.