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Irradiating the whole body, or just the bones and marrow, to wipe out the patient's blood system and immune cells before a stem cell transplant.
Total body irradiation in several fractions over a few days, combined with chemotherapy, conditions patients for allogeneic transplant by killing residual leukaemia and suppressing the immune system so the donor graft can take. It remains standard for children and young adults with acute lymphoblastic leukaemia, where the FORUM trial showed better survival than chemotherapy-only conditioning. Total marrow and lymphoid irradiation uses IMRT or helical delivery to concentrate the dose on bone marrow and lymph nodes while sparing lungs, eyes and gut, allowing dose escalation or gentler conditioning.
A uniform (or marrow-targeted) dose to the entire haematopoietic system eradicates host marrow and immune cells before donor cells are infused.
Query for this technology: (TITLE:"Total body and total marrow irradiation" OR ABSTRACT:"Total body and total marrow irradiation") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Total body and total marrow irradiation, not a curated reading list.
Shares TomoTherapy and Radixact (helical radiotherapy), IMRT / IGRT (modern external beam) and the tag radiation-wave1.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave1.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave1.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave1.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave1.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave1.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave1.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave1.