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ZNF703 (Zinc finger protein 703) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Letrozole and Ribociclib.
In plain words · ZNF703 (Zinc finger protein 703) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
ZNF703 (Zinc finger protein 703) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation.
No product in this corpus aims at ZNF703 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ZNF703: RNA tissue enhanced (skeletal muscle 105 nTPM); blood lineage lineage enriched (monocytes 4 nTPM); high antibody staining in 1 normal tissue; highest cancer staining breast cancer (5 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas ZNF703 tissue; Open Targets ENSG00000183779 associations
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:25883 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H7S9 (protein name, function text, keywords and locations (REST API)); CIViC gene ZNF703 (1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0))
Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. Location: Nucleus; Cytoplasm (UniProt). Locus 8p11.23 (HGNC).
RNA: tissue enhanced (skeletal muscle 105 nTPM), detected in many normal tissues. Blood: lineage enriched (monocytes 4 nTPM).
Medium: Adipose tissue, Adrenal gland, Appendix, Breast, Bronchus, Caudate, Cerebellum, Cerebral cortex.
Medium only: carcinoid, cervical cancer, endometrial cancer, glioma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ZNF703" OR ABSTRACT:"ZNF703" OR TITLE:"zinc finger protein 703" OR ABSTRACT:"zinc finger protein 703" OR TITLE:"Zinc finger protein 703" OR ABSTRACT:"Zinc finger protein 703" OR TITLE:"FLJ14299" OR ABSTRACT:"FLJ14299" OR TITLE:"ZNF503L" OR ABSTRACT:"ZNF503L" OR TITLE:"NLZ1" OR ABSTRACT:"NLZ1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF703, not a curated reading list.