{"entity":{"id":"znf703","kind":"target","name":"ZNF703","aka":["zinc finger protein 703","Zinc finger protein 703","FLJ14299","ZNF503L","NLZ1","Zpo1","ZEPPO1"],"tldr":"ZNF703 (Zinc finger protein 703) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.","summary":"Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Letrozole and Ribociclib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25883","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25883"},{"label":"UniProt Q9H7S9","url":"https://www.uniprot.org/uniprotkb/Q9H7S9/entry"},{"label":"NCBI Gene 80139","url":"https://www.ncbi.nlm.nih.gov/gene/80139"},{"label":"Ensembl ENSG00000183779","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183779"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZNF703","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:25883","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25883","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9H7S9","url":"https://www.uniprot.org/uniprotkb/Q9H7S9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ZNF703","url":"https://civicdb.org/features/15283","note":"1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ZNF703: RNA tissue enhanced (skeletal muscle 105 nTPM); blood lineage lineage enriched (monocytes 4 nTPM); high antibody staining in 1 normal tissue; highest cancer staining breast cancer (5 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas ZNF703 tissue","url":"https://www.proteinatlas.org/ENSG00000183779-ZNF703/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000183779 associations","url":"https://platform.opentargets.org/target/ENSG00000183779/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:25883","ensembl":"ENSG00000183779","uniprot":"Q9H7S9","entrez":"80139","firstDescribed":2004,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, \"Complete sequencing and characterization of 21,243 full-length human cDNAs\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/14702039/","biology":"Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. Location: Nucleus; Cytoplasm (UniProt). Locus 8p11.23 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/znf703/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}