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ZNF462 (Zinc finger protein 462) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organisation. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerisation of PBX1 and HOXA9 and their binding to DNA.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.17, animal model 0.34, genetic association 0.77).
In plain words · ZNF462 (Zinc finger protein 462) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
ZNF462 (Zinc finger protein 462) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organisation. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG.
No product in this corpus aims at ZNF462 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2001. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2001, "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:21684 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96JM2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000148143 (association with cancer (MONDO_0004992) 0.59; (GraphQL API, CC0))
Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organisation. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerisation of PBX1 and HOXA9 and their binding to DNA. Regulates neuronal development and neural cell differentiation. Location: Nucleus (UniProt). Locus 9q31.2 (HGNC).
Query for this target: (TITLE:"ZNF462" OR ABSTRACT:"ZNF462" OR TITLE:"zinc finger protein 462" OR ABSTRACT:"zinc finger protein 462" OR TITLE:"Zinc finger protein 462" OR ABSTRACT:"Zinc finger protein 462" OR TITLE:"DKFZP762N2316" OR ABSTRACT:"DKFZP762N2316" OR TITLE:"KIAA1803" OR ABSTRACT:"KIAA1803" OR TITLE:"Zfp462" OR ABSTRACT:"Zfp462") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF462, not a curated reading list.