{"entity":{"id":"znf462","kind":"target","name":"ZNF462","aka":["zinc finger protein 462","Zinc finger protein 462","DKFZP762N2316","KIAA1803","Zfp462"],"tldr":"ZNF462 (Zinc finger protein 462) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organisation. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerisation of PBX1 and HOXA9 and their binding to DNA.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.17, animal model 0.34, genetic association 0.77).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:21684","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21684"},{"label":"UniProt Q96JM2","url":"https://www.uniprot.org/uniprotkb/Q96JM2/entry"},{"label":"NCBI Gene 58499","url":"https://www.ncbi.nlm.nih.gov/gene/58499"},{"label":"Ensembl ENSG00000148143","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000148143"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZNF462","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:21684","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21684","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96JM2","url":"https://www.uniprot.org/uniprotkb/Q96JM2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000148143","url":"https://platform.opentargets.org/target/ENSG00000148143/associations","note":"association with cancer (MONDO_0004992) 0.59;  (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:21684","ensembl":"ENSG00000148143","uniprot":"Q96JM2","entrez":"58499","firstDescribed":2001,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2001, \"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/11347906/","biology":"Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organisation. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerisation of PBX1 and HOXA9 and their binding to DNA. Regulates neuronal development and neural cell differentiation. Location: Nucleus (UniProt). Locus 9q31.2 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/znf462/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}