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ZNF292 (Zinc finger protein 292) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
May be involved in transcriptional regulation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · ZNF292 (Zinc finger protein 292) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
ZNF292 (Zinc finger protein 292) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
May be involved in transcriptional regulation. Location: Nucleus (UniProt).
No product in this corpus aims at ZNF292 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA ZNF292: RNA low tissue specificity; no normal tissue stained high; highest cancer staining colorectal cancer (1 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas ZNF292 tissue; Open Targets ENSG00000188994 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". Source.
Sources: HGNC HGNC:18410 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O60281 (protein name, function text, keywords and locations (REST API)); CIViC gene ZNF292 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 6q14.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
Medium only: breast cancer, cervical cancer, endometrial cancer, head and neck cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ZNF292" OR ABSTRACT:"ZNF292" OR TITLE:"zinc finger protein 292" OR ABSTRACT:"zinc finger protein 292" OR TITLE:"Zinc finger protein 292" OR ABSTRACT:"Zinc finger protein 292" OR TITLE:"KIAA0530" OR ABSTRACT:"KIAA0530" OR TITLE:"ZFP292" OR ABSTRACT:"ZFP292" OR TITLE:"bA393I2.3" OR ABSTRACT:"bA393I2.3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF292, not a curated reading list.