{"entity":{"id":"znf292","kind":"target","name":"ZNF292","aka":["zinc finger protein 292","Zinc finger protein 292","KIAA0530","ZFP292","bA393I2.3","Zn-15","Zn-16"],"tldr":"ZNF292 (Zinc finger protein 292) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"May be involved in transcriptional regulation.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18410","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18410"},{"label":"UniProt O60281","url":"https://www.uniprot.org/uniprotkb/O60281/entry"},{"label":"NCBI Gene 23036","url":"https://www.ncbi.nlm.nih.gov/gene/23036"},{"label":"Ensembl ENSG00000188994","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000188994"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZNF292","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:18410","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18410","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O60281","url":"https://www.uniprot.org/uniprotkb/O60281/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ZNF292","url":"https://civicdb.org/features/9236","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA ZNF292: RNA low tissue specificity; no normal tissue stained high; highest cancer staining colorectal cancer (1 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas ZNF292 tissue","url":"https://www.proteinatlas.org/ENSG00000188994-ZNF292/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000188994 associations","url":"https://platform.opentargets.org/target/ENSG00000188994/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:18410","ensembl":"ENSG00000188994","uniprot":"O60281","entrez":"23036","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, \"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9628581/","biology":"May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 6q14.3 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/znf292/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}