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ZC3HAV1 (Zinc finger CCCH-type antiviral protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.64, affected pathway 0.89, genetic association 0.00).
In plain words · ZC3HAV1 (Zinc finger CCCH-type antiviral protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
ZC3HAV1 (Zinc finger CCCH-type antiviral protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs.
No product in this corpus aims at ZC3HAV1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Zhang et al, 1999, "Functional prediction of the coding sequences of 5 new genes deduced by analysis of cDNA clones from human fetal liver". Source.
Sources: HGNC HGNC:23721 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7Z2W4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000105939 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae, including human immunodeficiency virus type 1, filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Exhibits stronger antiviral activity than isoform 2 against MuLV expression and Semliki forest virus infection. Location: Nucleus; Lysosome; Late endosome; Cytoplasm (UniProt). Locus 7q34 (HGNC).
Query for this target: (TITLE:"ZC3HAV1" OR ABSTRACT:"ZC3HAV1" OR TITLE:"zinc finger CCCH-type containing, antiviral 1" OR ABSTRACT:"zinc finger CCCH-type containing, antiviral 1" OR TITLE:"Zinc finger CCCH-type antiviral protein 1" OR ABSTRACT:"Zinc finger CCCH-type antiviral protein 1" OR TITLE:"FLB6421" OR ABSTRACT:"FLB6421" OR TITLE:"FLJ13288" OR ABSTRACT:"FLJ13288" OR TITLE:"MGC48898" OR ABSTRACT:"MGC48898") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZC3HAV1, not a curated reading list.