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ZC3HAV1 (Zinc finger CCCH-type antiviral protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae, including human immunodeficiency virus type 1, filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Exhibits stronger antiviral activity than isoform 2 against MuLV expression and Semliki forest virus infection. Location: Nucleus; Lysosome; Late endosome; Cytoplasm (UniProt). Locus 7q34 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"ZC3HAV1" OR ABSTRACT:"ZC3HAV1" OR TITLE:"zinc finger CCCH-type containing, antiviral 1" OR ABSTRACT:"zinc finger CCCH-type containing, antiviral 1" OR TITLE:"Zinc finger CCCH-type antiviral protein 1" OR ABSTRACT:"Zinc finger CCCH-type antiviral protein 1" OR TITLE:"FLB6421" OR ABSTRACT:"FLB6421" OR TITLE:"FLJ13288" OR ABSTRACT:"FLJ13288" OR TITLE:"MGC48898" OR ABSTRACT:"MGC48898") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZC3HAV1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/zc3hav1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/zc3hav1.json. Licence CC BY-NC 4.0.