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XRCC1 (DNA repair protein XRCC1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Cervical cancer and Non-small-cell lung cancer.
Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognises and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity.
CIViC holds 3 clinical evidence items and 0 assertions across 2 variants, naming Docetaxel, Gemcitabine, Carboplatin and Vinorelbine and others. Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.78).
In plain words · XRCC1 (DNA repair protein XRCC1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Cervical cancer and Non-small-cell lung cancer.
XRCC1 (DNA repair protein XRCC1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Cervical cancer and Non-small-cell lung cancer.
Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes.
No product in this corpus aims at XRCC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA XRCC1: RNA low tissue specificity; high antibody staining in 35 normal tissues; highest cancer staining urothelial cancer (12 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Cervical cancer, Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas XRCC1 tissue; Open Targets ENSG00000073050 associations
First described 1990. Earliest sequence paper UniProt cites for the protein: Thompson L.H. et al, Mol. Cell. Biol, 1990, "Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange". Source.
Sources: HGNC HGNC:12828 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P18887 (protein name, function text, keywords and locations (REST API)); CIViC gene XRCC1 (3 evidence items, 0 assertions, 2 variants; diseases: Lung Non-small Cell Carcinoma, Cervical Cancer (GraphQL API, CC0)); Open Targets ENSG00000073050 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognises and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity. Location: Nucleus; Chromosome (UniProt). Locus 19q13.31 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Duodenum, Lymph node, Prostate, Seminal vesicle, Smooth muscle, Soft tissue.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"XRCC1" OR ABSTRACT:"XRCC1" OR TITLE:"X-ray repair cross complementing 1" OR ABSTRACT:"X-ray repair cross complementing 1" OR TITLE:"DNA repair protein XRCC1" OR ABSTRACT:"DNA repair protein XRCC1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about XRCC1, not a curated reading list.