Loading
WNT6 (Wnt family member 6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signalling molecule which affects the development of discrete regions of tissues.
CIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Aspirin.
In plain words · WNT6 (Wnt family member 6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
WNT6 (Wnt family member 6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
No product in this corpus aims at WNT6 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA WNT6: RNA tissue enhanced (brain 10 nTPM); high antibody staining in 3 normal tissues. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas WNT6 tissue; Open Targets ENSG00000115596 associations
First described 1999. Earliest sequence paper UniProt cites for the protein: Rankin et al, Cytogenet. Cell Genet, 1999, "Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization". Source.
Sources: HGNC HGNC:12785 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y6F9 (protein name, function text, keywords and locations (REST API)); CIViC gene WNT6 (1 evidence items, 0 assertions, 2 variants; diseases: Colorectal Cancer (GraphQL API, CC0))
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signalling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signalling pathway. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 2q35 (HGNC).
RNA: tissue enhanced (brain 10 nTPM), detected in many normal tissues.
Medium: Adrenal gland, Bone marrow, Bronchus, Colon, Duodenum, Endometrium, Gallbladder, Hippocampus.
RNA group enriched: Bladder Urothelial Carcinoma 4 pTPM, Ovary Serous Cystadenocarcinoma 12 pTPM, Uterine Corpus Endometrial Carcinoma 4 pTPM.
No cancer stained high; medium in breast cancer, endometrial cancer, liver cancer, lung cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"WNT6" OR ABSTRACT:"WNT6" OR TITLE:"Wnt family member 6" OR ABSTRACT:"Wnt family member 6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about WNT6, not a curated reading list.