{"entity":{"id":"wnt6","kind":"target","name":"WNT6","aka":["Wnt family member 6"],"tldr":"WNT6 (Wnt family member 6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.","summary":"Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signalling molecule which affects the development of discrete regions of tissues.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Aspirin.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12785","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12785"},{"label":"UniProt Q9Y6F9","url":"https://www.uniprot.org/uniprotkb/Q9Y6F9/entry"},{"label":"NCBI Gene 7475","url":"https://www.ncbi.nlm.nih.gov/gene/7475"},{"label":"Ensembl ENSG00000115596","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115596"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"WNT6","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:12785","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12785","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y6F9","url":"https://www.uniprot.org/uniprotkb/Q9Y6F9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene WNT6","url":"https://civicdb.org/features/6113","note":"1 evidence items, 0 assertions, 2 variants; diseases: Colorectal Cancer (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA WNT6: RNA tissue enhanced (brain 10 nTPM); high antibody staining in 3 normal tissues. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas WNT6 tissue","url":"https://www.proteinatlas.org/ENSG00000115596-WNT6/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000115596 associations","url":"https://platform.opentargets.org/target/ENSG00000115596/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:12785","ensembl":"ENSG00000115596","uniprot":"Q9Y6F9","entrez":"7475","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Rankin et al, Cytogenet. Cell Genet, 1999, \"Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10343101/","biology":"Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signalling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signalling pathway. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 2q35 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/wnt6/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}