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WNT11 (Wnt family member 11) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signalling molecule which affects the development of discrete regions of tissues.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · WNT11 (Wnt family member 11) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
WNT11 (Wnt family member 11) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
No product in this corpus aims at WNT11 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA WNT11: RNA tissue enhanced (adipose tissue 36 nTPM); blood lineage lineage enriched (NK-cells 3 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas WNT11 tissue; Open Targets ENSG00000085741 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Lako et al, Gene, 1998, "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung". Source.
Sources: HGNC HGNC:12776 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O96014 (protein name, function text, keywords and locations (REST API)); CIViC gene WNT11 (1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0))
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signalling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 11q13.5 (HGNC).
RNA: tissue enhanced (adipose tissue 36 nTPM), detected in many normal tissues. Blood: lineage enriched (NK-cells 3 nTPM).
No normal tissue stained high.
No cancer stained high; medium in carcinoid, cervical cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"WNT11" OR ABSTRACT:"WNT11" OR TITLE:"Wnt family member 11" OR ABSTRACT:"Wnt family member 11") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about WNT11, not a curated reading list.