{"entity":{"id":"wnt11","kind":"target","name":"WNT11","aka":["Wnt family member 11"],"tldr":"WNT11 (Wnt family member 11) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.","summary":"Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signalling molecule which affects the development of discrete regions of tissues.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12776","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12776"},{"label":"UniProt O96014","url":"https://www.uniprot.org/uniprotkb/O96014/entry"},{"label":"NCBI Gene 7481","url":"https://www.ncbi.nlm.nih.gov/gene/7481"},{"label":"Ensembl ENSG00000085741","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085741"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"WNT11","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:12776","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12776","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O96014","url":"https://www.uniprot.org/uniprotkb/O96014/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene WNT11","url":"https://civicdb.org/features/6119","note":"1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA WNT11: RNA tissue enhanced (adipose tissue 36 nTPM); blood lineage lineage enriched (NK-cells 3 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas WNT11 tissue","url":"https://www.proteinatlas.org/ENSG00000085741-WNT11/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000085741 associations","url":"https://platform.opentargets.org/target/ENSG00000085741/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:12776","ensembl":"ENSG00000085741","uniprot":"O96014","entrez":"7481","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Lako et al, Gene, 1998, \"Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9757009/","biology":"Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signalling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 11q13.5 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/wnt11/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}