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VPS37A (Vacuolar protein sorting-associated protein 37A) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cetuximab.
In plain words · VPS37A (Vacuolar protein sorting-associated protein 37A) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
VPS37A (Vacuolar protein sorting-associated protein 37A) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.
No product in this corpus aims at VPS37A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists VPS37A among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA VPS37A: RNA low tissue specificity; high antibody staining in 1 normal tissue. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Ovarian cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas VPS37A tissue; Open Targets ENSG00000155975 associations
First described 2003. Earliest sequence paper UniProt cites for the protein: Xu et al, Biochem. Biophys. Res. Commun, 2003, "HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein". Source.
Sources: HGNC HGNC:24928 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8NEZ2 (protein name, function text, keywords and locations (REST API)); CIViC gene VPS37A (1 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0))
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Location: Late endosome membrane; Nucleus (UniProt). Locus 8p22 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Appendix, Bone marrow, Bronchus, Caudate, Cerebellum, Cerebral cortex, Colon.
No cancer stained high; medium in breast cancer, carcinoid, cervical cancer, colorectal cancer.
HPA VPS37A tissue · HPA VPS37A pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"VPS37A" OR ABSTRACT:"VPS37A" OR TITLE:"VPS37A subunit of ESCRT-I" OR ABSTRACT:"VPS37A subunit of ESCRT-I" OR TITLE:"Vacuolar protein sorting-associated protein 37A" OR ABSTRACT:"Vacuolar protein sorting-associated protein 37A" OR TITLE:"FLJ32642" OR ABSTRACT:"FLJ32642" OR TITLE:"HCRP1" OR ABSTRACT:"HCRP1" OR TITLE:"SPG53" OR ABSTRACT:"SPG53") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VPS37A, not a curated reading list.