{"entity":{"id":"vps37a","kind":"target","name":"VPS37A","aka":["VPS37A subunit of ESCRT-I","Vacuolar protein sorting-associated protein 37A","FLJ32642","HCRP1","SPG53","PQBP2"],"tldr":"VPS37A (Vacuolar protein sorting-associated protein 37A) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.","summary":"Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cetuximab.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:24928","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24928"},{"label":"UniProt Q8NEZ2","url":"https://www.uniprot.org/uniprotkb/Q8NEZ2/entry"},{"label":"NCBI Gene 137492","url":"https://www.ncbi.nlm.nih.gov/gene/137492"},{"label":"Ensembl ENSG00000155975","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000155975"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"VPS37A","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:24928","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24928","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8NEZ2","url":"https://www.uniprot.org/uniprotkb/Q8NEZ2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene VPS37A","url":"https://civicdb.org/features/18353","note":"1 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA lists VPS37A among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA VPS37A: RNA low tissue specificity; high antibody staining in 1 normal tissue. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Ovarian cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas VPS37A tissue","url":"https://www.proteinatlas.org/ENSG00000155975-VPS37A/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000155975 associations","url":"https://platform.opentargets.org/target/ENSG00000155975/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:24928","ensembl":"ENSG00000155975","uniprot":"Q8NEZ2","entrez":"137492","firstDescribed":2003,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Xu et al, Biochem. Biophys. Res. Commun, 2003, \"HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/14623289/","biology":"Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Location: Late endosome membrane; Nucleus (UniProt). Locus 8p22 (HGNC).","whereFound":["Ovarian cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/vps37a/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}