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USP8 (Ubiquitin carboxyl-terminal hydrolase 8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Multiple myeloma, Breast cancer and 1 more.
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.85). IntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma, Plasma Cell Myeloma.
In plain words · USP8 (Ubiquitin carboxyl-terminal hydrolase 8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Multiple myeloma, Breast cancer and 1 more.
USP8 (Ubiquitin carboxyl-terminal hydrolase 8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Multiple myeloma, Breast cancer and 1 more.
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains.
No product in this corpus aims at USP8 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1994. Earliest sequence paper UniProt cites for the protein: Nomura et al, DNA Res, 1994, "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". Source.
Sources: HGNC HGNC:12631 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P40818 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000138592 (association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: breast cancer 0.53 (GraphQL API, CC0)); IntOGen USP8 (driver in 3 cohorts (Act 3, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Location: Cytoplasm; Nucleus; Endosome membrane; Cell membrane (UniProt). Locus 15q21.2 (HGNC).
Query for this target: (TITLE:"USP8" OR ABSTRACT:"USP8" OR TITLE:"ubiquitin specific peptidase 8" OR ABSTRACT:"ubiquitin specific peptidase 8" OR TITLE:"Ubiquitin carboxyl-terminal hydrolase 8" OR ABSTRACT:"Ubiquitin carboxyl-terminal hydrolase 8" OR TITLE:"HumORF8" OR ABSTRACT:"HumORF8" OR TITLE:"KIAA0055" OR ABSTRACT:"KIAA0055" OR TITLE:"SPG59" OR ABSTRACT:"SPG59") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about USP8, not a curated reading list.