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USP8 (Ubiquitin carboxyl-terminal hydrolase 8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Multiple myeloma, Breast cancer and 1 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Location: Cytoplasm; Nucleus; Endosome membrane; Cell membrane (UniProt). Locus 15q21.2 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"USP8" OR ABSTRACT:"USP8" OR TITLE:"ubiquitin specific peptidase 8" OR ABSTRACT:"ubiquitin specific peptidase 8" OR TITLE:"Ubiquitin carboxyl-terminal hydrolase 8" OR ABSTRACT:"Ubiquitin carboxyl-terminal hydrolase 8" OR TITLE:"HumORF8" OR ABSTRACT:"HumORF8" OR TITLE:"KIAA0055" OR ABSTRACT:"KIAA0055" OR TITLE:"SPG59" OR ABSTRACT:"SPG59") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about USP8, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/usp8.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/usp8.json. Licence CC BY-NC 4.0.