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TYRP1 (5,6-dihydroxyindole-2-carboxylic acid oxidase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
Plays a role in melanin biosynthesis. Catalyses the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesised.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.56, animal model 0.63, genetic association 0.70).
In plain words · TYRP1 (5,6-dihydroxyindole-2-carboxylic acid oxidase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
TYRP1 (5,6-dihydroxyindole-2-carboxylic acid oxidase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
Plays a role in melanin biosynthesis. Catalyses the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+).
No product in this corpus aims at TYRP1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1990. Earliest sequence paper UniProt cites for the protein: Cohen et al, Nucleic Acids Res, 1990, "Nucleotide sequence of the cDNA encoding human tyrosinase-related protein". Source.
Sources: HGNC HGNC:12450 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P17643 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107165 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: skin cancer 0.53 (GraphQL API, CC0))
Plays a role in melanin biosynthesis. Catalyses the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesised. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. Location: Melanosome membrane (UniProt). Locus 9p23 (HGNC).
Query for this target: (TITLE:"TYRP1" OR ABSTRACT:"TYRP1" OR TITLE:"tyrosinase related protein 1" OR ABSTRACT:"tyrosinase related protein 1" OR TITLE:"5,6-dihydroxyindole-2-carboxylic acid oxidase" OR ABSTRACT:"5,6-dihydroxyindole-2-carboxylic acid oxidase" OR TITLE:"GP75" OR ABSTRACT:"GP75" OR TITLE:"b-PROTEIN" OR ABSTRACT:"b-PROTEIN" OR TITLE:"OCA3" OR ABSTRACT:"OCA3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TYRP1, not a curated reading list.