Loading
TYRP1 (5,6-dihydroxyindole-2-carboxylic acid oxidase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Plays a role in melanin biosynthesis. Catalyses the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesised. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. Location: Melanosome membrane (UniProt). Locus 9p23 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"TYRP1" OR ABSTRACT:"TYRP1" OR TITLE:"tyrosinase related protein 1" OR ABSTRACT:"tyrosinase related protein 1" OR TITLE:"5,6-dihydroxyindole-2-carboxylic acid oxidase" OR ABSTRACT:"5,6-dihydroxyindole-2-carboxylic acid oxidase" OR TITLE:"GP75" OR ABSTRACT:"GP75" OR TITLE:"b-PROTEIN" OR ABSTRACT:"b-PROTEIN" OR TITLE:"OCA3" OR ABSTRACT:"OCA3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TYRP1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/tyrp1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/tyrp1.json. Licence CC BY-NC 4.0.