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TYMP (Thymidine phosphorylase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Colorectal cancer.
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyses the reversible phosphorolysis of thymidine.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.46, clinical 0.93).
In plain words · TYMP (Thymidine phosphorylase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Colorectal cancer.
TYMP (Thymidine phosphorylase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Colorectal cancer.
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
No product in this corpus aims at TYMP yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA TYMP: RNA low tissue specificity; blood lineage group enriched (dendritic cells 40 nTPM, granulocytes 116 nTPM, monocytes 137 nTPM); no normal tissue stained high; highest cancer staining head and neck cancer (2 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 1 specific cancer type at or above 0.5 (colorectal cancer). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas TYMP tissue; Open Targets ENSG00000025708 associations
First described 1989. Earliest sequence paper UniProt cites for the protein: Ishikawa et al, Nature, 1989, "Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor". Source.
Sources: HGNC HGNC:3148 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P19971 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000025708 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: colorectal cancer 0.58 (GraphQL API, CC0))
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyses the reversible phosphorolysis of thymidine. The produced molecules are then utilised as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Locus 22q13.33 (HGNC).
RNA: low tissue specificity, detected in many normal tissues. Blood: group enriched (dendritic cells 40 nTPM, granulocytes 116 nTPM, monocytes 137 nTPM).
No normal tissue stained high; medium in Appendix, Bone marrow, Lung, Lymph node, Skin, Spleen and more.
RNA cancer enhanced: Head and Neck Squamous Cell Carcinoma 543 pTPM.
Medium only: endometrial cancer, liver cancer, ovarian cancer, pancreatic cancer.
HPA TYMP tissue · HPA TYMP pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TYMP" OR ABSTRACT:"TYMP" OR TITLE:"thymidine phosphorylase" OR ABSTRACT:"thymidine phosphorylase" OR TITLE:"Thymidine phosphorylase" OR ABSTRACT:"Thymidine phosphorylase" OR TITLE:"MNGIE" OR ABSTRACT:"MNGIE" OR TITLE:"ECGF1" OR ABSTRACT:"ECGF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TYMP, not a curated reading list.