{"entity":{"id":"tymp","kind":"target","name":"TYMP","aka":["thymidine phosphorylase","Thymidine phosphorylase","MNGIE","ECGF1"],"tldr":"TYMP (Thymidine phosphorylase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Colorectal cancer.","summary":"May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyses the reversible phosphorolysis of thymidine.\n\nOpen Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.46, clinical 0.93).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3148","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3148"},{"label":"UniProt P19971","url":"https://www.uniprot.org/uniprotkb/P19971/entry"},{"label":"NCBI Gene 1890","url":"https://www.ncbi.nlm.nih.gov/gene/1890"},{"label":"Ensembl ENSG00000025708","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000025708"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.93. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TYMP","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:3148","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3148","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P19971","url":"https://www.uniprot.org/uniprotkb/P19971/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000025708","url":"https://platform.opentargets.org/target/ENSG00000025708/associations","note":"association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: colorectal cancer 0.58 (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA TYMP: RNA low tissue specificity; blood lineage group enriched (dendritic cells 40 nTPM, granulocytes 116 nTPM, monocytes 137 nTPM); no normal tissue stained high; highest cancer staining head and neck cancer (2 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 1 specific cancer type at or above 0.5 (colorectal cancer). (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas TYMP tissue","url":"https://www.proteinatlas.org/ENSG00000025708-TYMP/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000025708 associations","url":"https://platform.opentargets.org/target/ENSG00000025708/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3148","ensembl":"ENSG00000025708","uniprot":"P19971","entrez":"1890","firstDescribed":1989,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ishikawa et al, Nature, 1989, \"Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2467210/","biology":"May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyses the reversible phosphorolysis of thymidine. The produced molecules are then utilised as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Locus 22q13.33 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.58 with colorectal cancer (MONDO_0005575)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/tymp/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}