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TUBB3 (Tubulin beta-3 chain) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Prostate cancer and 5 more.
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Paclitaxel and Taxane Compound. Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes clinical 1.00, affected pathway 0.61, literature 0.95, genetic association 0.28, somatic mutation 0.23, animal model 0.36).
In plain words · TUBB3 (Tubulin beta-3 chain) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Prostate cancer and 5 more.
TUBB3 (Tubulin beta-3 chain) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Prostate cancer and 5 more.
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms.
No product in this corpus aims at TUBB3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TUBB3: RNA tissue enriched (brain 344 nTPM); blood lineage lineage enriched (B-cells 3 nTPM); high antibody staining in 2 normal tissues. Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Lung cancer (all types), Prostate cancer, Lymphoma, Sarcomas (soft tissue, bone, GIST), Cervical cancer, Multiple myeloma); Open Targets associates it with 19 specific cancer types at or above 0.5 (breast cancer, non-small cell lung carcinoma, breast carcinoma, prostate cancer, Hodgkins lymphoma, cervical cancer and more). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas TUBB3 tissue; Open Targets ENSG00000258947 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Ranganathan et al, Biochim. Biophys. Acta, 1998, "Cloning and sequencing of human betaIII-tubulin cDNA: induction of betaIII isotype in human prostate carcinoma cells by acute exposure to antimicrotubule agents". Source.
Sources: HGNC HGNC:20772 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13509 (protein name, function text, keywords and locations (REST API)); CIViC gene TUBB3 (2 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer, Cancer (GraphQL API, CC0)); Open Targets ENSG00000258947 (association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.62, gastric cancer 0.55, prostate cancer 0.63, ovarian cancer 0.58, cervical cancer 0.59, head and neck squamous cell carcinoma 0.54 (GraphQL API, CC0))
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerised TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. Location: Cytoplasm, cytoskeleton; Cell projection, growth cone; Cell projection, lamellipodium; Cell projection, filopodium (UniProt). Locus 16q24.3 (HGNC).
RNA: tissue enriched (brain 344 nTPM), detected in many normal tissues. Blood: lineage enriched (B-cells 3 nTPM).
Medium: Cerebral cortex, Colon, Hippocampus.
No cancer stained high; medium in carcinoid, endometrial cancer, glioma, ovarian cancer.
HPA TUBB3 tissue · HPA TUBB3 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TUBB3" OR ABSTRACT:"TUBB3" OR TITLE:"tubulin beta 3 class III" OR ABSTRACT:"tubulin beta 3 class III" OR TITLE:"Tubulin beta-3 chain" OR ABSTRACT:"Tubulin beta-3 chain" OR TITLE:"beta-4" OR ABSTRACT:"beta-4" OR TITLE:"CFEOM3" OR ABSTRACT:"CFEOM3" OR TITLE:"CFEOM3A" OR ABSTRACT:"CFEOM3A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBB3, not a curated reading list.