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TTF1 (Transcription termination factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · TTF1 (Transcription termination factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
TTF1 (Transcription termination factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin.
No product in this corpus aims at TTF1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA lists TTF1 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA TTF1: RNA low tissue specificity; high antibody staining in 21 normal tissues; highest cancer staining testis cancer (11 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas TTF1 tissue; Open Targets ENSG00000125482 associations
First described 1995. Earliest sequence paper UniProt cites for the protein: Evers et al, Proc. Natl. Acad. Sci. U.S.A, 1995, "Molecular evolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-1". Source.
Sources: HGNC HGNC:12397 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15361 (protein name, function text, keywords and locations (REST API)); CIViC gene TTF1 (1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0))
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. Location: Nucleus; Nucleus, nucleolus; Nucleus, nucleoplasm (UniProt). Locus 9q34.13 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Appendix, Breast, Bronchus, Caudate, Gallbladder, Heart muscle, Hippocampus.
Medium only: lymphoma, renal cancer, thyroid cancer.
HPA TTF1 tissue · HPA TTF1 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TTF1" OR ABSTRACT:"TTF1" OR TITLE:"transcription termination factor 1" OR ABSTRACT:"transcription termination factor 1" OR TITLE:"Transcription termination factor 1" OR ABSTRACT:"Transcription termination factor 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TTF1, not a curated reading list.