{"entity":{"id":"ttf1","kind":"target","name":"TTF1","aka":["transcription termination factor 1","Transcription termination factor 1"],"tldr":"TTF1 (Transcription termination factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.","summary":"Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12397","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12397"},{"label":"UniProt Q15361","url":"https://www.uniprot.org/uniprotkb/Q15361/entry"},{"label":"NCBI Gene 7270","url":"https://www.ncbi.nlm.nih.gov/gene/7270"},{"label":"Ensembl ENSG00000125482","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125482"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TTF1","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:12397","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12397","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15361","url":"https://www.uniprot.org/uniprotkb/Q15361/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TTF1","url":"https://civicdb.org/features/80","note":"1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA lists TTF1 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA TTF1: RNA low tissue specificity; high antibody staining in 21 normal tissues; highest cancer staining testis cancer (11 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas TTF1 tissue","url":"https://www.proteinatlas.org/ENSG00000125482-TTF1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000125482 associations","url":"https://platform.opentargets.org/target/ENSG00000125482/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:12397","ensembl":"ENSG00000125482","uniprot":"Q15361","entrez":"7270","firstDescribed":1995,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Evers et al, Proc. Natl. Acad. Sci. U.S.A, 1995, \"Molecular evolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-1\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/7597036/","biology":"Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. Location: Nucleus; Nucleus, nucleolus; Nucleus, nucleoplasm (UniProt). Locus 9q34.13 (HGNC).","whereFound":["Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/ttf1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}