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TSPYL1 (Testis-specific Y-encoded-like protein 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
UniProt has no function text for Q9H0U9; HGNC names it "TSPY like 1".
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Abiraterone and Prednisone.
In plain words · TSPYL1 (Testis-specific Y-encoded-like protein 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
TSPYL1 (Testis-specific Y-encoded-like protein 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
UniProt has no function text for Q9H0U9; HGNC names it "TSPY like 1". Location: Nucleus, nucleolus (UniProt).
No product in this corpus aims at TSPYL1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA TSPYL1: RNA low tissue specificity; high antibody staining in 26 normal tissues; highest cancer staining thyroid cancer (4 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Prostate cancer); Open Targets associates it with 1 specific cancer type at or above 0.5 (sudden infant death-dysgenesis of the testes syndrome). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas TSPYL1 tissue; Open Targets ENSG00000189241 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Vogel et al, Cytogenet. Cell Genet, 1998, "Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family". Source.
Sources: HGNC HGNC:12382 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H0U9 (protein name, function text, keywords and locations (REST API)); CIViC gene TSPYL1 (2 evidence items, 0 assertions, 2 variants; diseases: Prostate Cancer (GraphQL API, CC0))
UniProt has no function text for Q9H0U9; HGNC names it "TSPY like 1". Location: Nucleus, nucleolus (UniProt). Locus 6q22.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Appendix, Breast, Bronchus, Colon, Duodenum, Endometrium, Heart muscle, Liver.
Medium only: endometrial cancer, stomach cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TSPYL1" OR ABSTRACT:"TSPYL1" OR TITLE:"TSPY like 1" OR ABSTRACT:"TSPY like 1" OR TITLE:"Testis-specific Y-encoded-like protein 1" OR ABSTRACT:"Testis-specific Y-encoded-like protein 1" OR TITLE:"TSPYL" OR ABSTRACT:"TSPYL") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TSPYL1, not a curated reading list.