{"entity":{"id":"tspyl1","kind":"target","name":"TSPYL1","aka":["TSPY like 1","Testis-specific Y-encoded-like protein 1","TSPYL"],"tldr":"TSPYL1 (Testis-specific Y-encoded-like protein 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.","summary":"UniProt has no function text for Q9H0U9; HGNC names it \"TSPY like 1\".\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Abiraterone and Prednisone.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12382","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12382"},{"label":"UniProt Q9H0U9","url":"https://www.uniprot.org/uniprotkb/Q9H0U9/entry"},{"label":"NCBI Gene 7259","url":"https://www.ncbi.nlm.nih.gov/gene/7259"},{"label":"Ensembl ENSG00000189241","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000189241"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TSPYL1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:12382","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12382","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9H0U9","url":"https://www.uniprot.org/uniprotkb/Q9H0U9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TSPYL1","url":"https://civicdb.org/features/5939","note":"2 evidence items, 0 assertions, 2 variants; diseases: Prostate Cancer (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA TSPYL1: RNA low tissue specificity; high antibody staining in 26 normal tissues; highest cancer staining thyroid cancer (4 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Prostate cancer); Open Targets associates it with 1 specific cancer type at or above 0.5 (sudden infant death-dysgenesis of the testes syndrome). (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas TSPYL1 tissue","url":"https://www.proteinatlas.org/ENSG00000189241-TSPYL1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000189241 associations","url":"https://platform.opentargets.org/target/ENSG00000189241/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:12382","ensembl":"ENSG00000189241","uniprot":"Q9H0U9","entrez":"7259","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Vogel et al, Cytogenet. Cell Genet, 1998, \"Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9730615/","biology":"UniProt has no function text for Q9H0U9; HGNC names it \"TSPY like 1\". Location: Nucleus, nucleolus (UniProt). Locus 6q22.1 (HGNC).","whereFound":["Prostate cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/tspyl1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}