Loading
The TSH receptor tells thyroid cells to take up iodine; recombinant TSH (thyrotropin alfa) stimulates it so that radioactive iodine can find and destroy leftover thyroid cancer.
The thyrotropin receptor on thyroid follicular cells drives iodine uptake and thyroglobulin production. After surgery for differentiated thyroid cancer, thyrotropin alfa (recombinant human TSH) stimulates the receptor on remaining normal and cancerous thyroid tissue so that radioiodine scanning and ablation work without stopping thyroid hormone replacement. Loss of TSHR and iodine transporter expression marks radioiodine-refractory disease.
In plain words · The TSH receptor tells thyroid cells to take up iodine; recombinant TSH (thyrotropin alfa) stimulates it so that radioactive iodine can find and destroy leftover thyroid cancer.
The TSH receptor tells thyroid cells to take up iodine; recombinant TSH (thyrotropin alfa) stimulates it so that radioactive iodine can find and destroy leftover thyroid cancer.
A G protein-coupled receptor signalling through cAMP; activating mutations cause hyperfunctioning nodules.
No product in this corpus aims at TSH receptor (TSHR) yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Tumour-associated overexpression: HPA finds the RNA cancer enriched in cancer (Thyroid Carcinoma (TCGA)) and tissue enriched in normal thyroid gland, so the tumour and the normal tissue it comes from share the target and the medicine relies on the difference in level. HPA TSHR: RNA tissue enriched (thyroid gland 257 nTPM); blood lineage group enriched (B-cells 2 nTPM, T-cells 7 nTPM); high antibody staining in 1 normal tissue; highest cancer staining liver cancer (1 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Thyroid cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas TSHR tissue; Human Protein Atlas TSHR pathology; Open Targets ENSG00000165409 associations
First described 1989. Earliest sequence paper UniProt cites for the protein: Nagayama et al, Biochem. Biophys. Res. Commun, 1989, "Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor". Source.
A G protein-coupled receptor signalling through cAMP; activating mutations cause hyperfunctioning nodules.
RNA: tissue enriched (thyroid gland 257 nTPM), detected in some normal tissues. Blood: group enriched (B-cells 2 nTPM, T-cells 7 nTPM).
Medium: Testis.
RNA cancer enriched: Thyroid Carcinoma 266 pTPM.
Medium only: breast cancer, colorectal cancer, lung cancer, ovarian cancer.
HPA TSHR tissue · HPA TSHR pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Thyroid cancer | host% | Host target: TSH receptor on thyroid cells, used to drive radioiodine uptake. Not a tumour alteration, so no prevalence applies; the drug acts on normal tissue or on symptoms. |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
Query for this target: (TITLE:"TSH receptor" OR ABSTRACT:"TSH receptor" OR TITLE:"TSHR" OR ABSTRACT:"TSHR") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TSH receptor (TSHR), not a curated reading list.
Shares Thyrotropin alfa, Thyroid cancer.
Shares Thyrotropin alfa, Thyroid cancer.
Shares Thyrotropin alfa, Thyroid cancer.
Shares Papillary thyroid cancer, Thyroid cancer.
Shares Papillary thyroid cancer, Thyroid cancer.
Shares Papillary thyroid cancer, Thyroid cancer.
Shares Papillary thyroid cancer, Thyroid cancer.
Shares Papillary thyroid cancer, Thyroid cancer.