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TRAK1 (Trafficking kinesin-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.39, affected pathway 0.89, animal model 0.36, genetic association 0.32).
In plain words · TRAK1 (Trafficking kinesin-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
TRAK1 (Trafficking kinesin-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility.
No product in this corpus aims at TRAK1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Kikuno et al, DNA Res, 1999, "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:29947 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UPV9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000182606 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria. Location: Cytoplasm; Nucleus; Mitochondrion; Early endosome (UniProt). Locus 3p22.1 (HGNC).
Query for this target: (TITLE:"TRAK1" OR ABSTRACT:"TRAK1" OR TITLE:"trafficking kinesin protein 1" OR ABSTRACT:"trafficking kinesin protein 1" OR TITLE:"Trafficking kinesin-binding protein 1" OR ABSTRACT:"Trafficking kinesin-binding protein 1" OR TITLE:"OIP106" OR ABSTRACT:"OIP106" OR TITLE:"KIAA1042" OR ABSTRACT:"KIAA1042" OR TITLE:"MILT1" OR ABSTRACT:"MILT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRAK1, not a curated reading list.