{"entity":{"id":"trak1","kind":"target","name":"TRAK1","aka":["trafficking kinesin protein 1","Trafficking kinesin-binding protein 1","OIP106","KIAA1042","MILT1"],"tldr":"TRAK1 (Trafficking kinesin-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.39, affected pathway 0.89, animal model 0.36, genetic association 0.32).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29947","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29947"},{"label":"UniProt Q9UPV9","url":"https://www.uniprot.org/uniprotkb/Q9UPV9/entry"},{"label":"NCBI Gene 22906","url":"https://www.ncbi.nlm.nih.gov/gene/22906"},{"label":"Ensembl ENSG00000182606","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000182606"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TRAK1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:29947","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29947","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UPV9","url":"https://www.uniprot.org/uniprotkb/Q9UPV9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000182606","url":"https://platform.opentargets.org/target/ENSG00000182606/associations","note":"association with cancer (MONDO_0004992) 0.61;  (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:29947","ensembl":"ENSG00000182606","uniprot":"Q9UPV9","entrez":"22906","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Kikuno et al, DNA Res, 1999, \"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10470851/","biology":"Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria. Location: Cytoplasm; Nucleus; Mitochondrion; Early endosome (UniProt). Locus 3p22.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/trak1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}